Hi, Thanks for the query.I understand your concern. *Myocyst m contains metformin .. the drug that controls non insulin dependent diabetes... It acts by improving insulin resistance .. thus suger in blood can be utilised & comes down Due to such actionit also helps in reducing weight ... which in turn controls insulin resistance. :* Increased body weight &insulin resistance can affect menstrual cycle.. by preventing ovulation.as is seen pcod. Your wife might have been prescribed the drug imperically -with this baground to help her 3rd round of iui . *I would suggest to test for ovulation (by lh surge/by usg ovulation study).. &then go for iui during her most fertile days.. In case of semen allergy your doctor may use steriods to avoid nonconception. Please be positive. Thanks.