sir, i am suffering from major depressive disorder since 1999 and taken antidepressants given by psychiatrists during last twelve years. at present i am taking medicines for D M TYPE-2, HYPERTENSION AND ANTIDEPRESSANTS such as 1-MIRTAZ-45 MG AT NIGHT. 2-LONAZEP IMG TAB - 1 TAB AT MORNING AND 1TAB AT NIGHT. 3-NEXITO 10MG 1TAB AT NIGHT. 4-VENLA-XR-150MG 1 CAP AT NIGHT. 5-PAXIDEP CR-25MG 1 TAB AT NIGHT. 6-PRAMIPEX 0.5MG TAB 1 TAB TWICE DAILY. but i am not well despite of taking all medicines and feeling depressed. sir, you are requested to resheduled and optimised the medicines and advised me for better medicines that i can lead a cheerful life. thanks, yours ever, k g agarwal, 45yrs, male, wt -95kg, businessman.