Hi thanks for your question.
is a disease which causes dysmenorrhea that is painful menstruation
a progesterone hormone.it is used for contraception
,normalizing the menstrual cycle and for dysmenorrhea.Registrone is safe to use for dysmenorrhea.However using it for dysmenorrhea for 12 years is not recommended. Other ways for treatment of endometriosis are also available. I would suggest you to consult a gynaecologist who may be able to treat your wife.
Hope this answers your question.