Thank you for your query. High blood sugar levels predominantly destroy the tiny blood vessels (micro vasculature) . Therefore all organs dependent on micro blood flow are at risk, these are the brain, eyes(retina), heart, kidney and peripheral nerves. Treatment consists of minimizing sugar intake (diet) , exercise , oral tablets and if at optimal dosages the sugar levels are too high one must ad insulin injections. At the levels you are reporting your husband needs insulin to bring the levels down. This has to be managed by a doctor well versed in treating diabetics, and will best to have him admitted to a hospital until his sugar is under control and his medication needs have been established. I trust this information is helpful .