Hi and welcome to HCM.
Permanent cure is surgical treatment
which is a routine today.Fissures are likely to be reccurent and usually it becomes inflammated many times during the life. ANtibiotics can help with infection but not with fissure- YOu can follow high fibre dietary, use laxatives and other medicines for easier defecation but this is also symtpomatic therapy. WIsh you good health.