Hello, Thanks for the query to H.C.M. Forum. If I were treating doctor of this severe pain ( of your husband) I would come up with these reasons. 1 The most important reason may be acute ( chronic ) gastritis with recurrent episode of pain due to various factor as radiotherapy for prostate cancer , drugs causing gastritis, tension ( of disease ) , stress . As you mentioned that endoscopy and colonoscopy didn t find any thing. In chronic gastritis usually we don t find any thing except mild erosion in lesser or greater curvature of stomach. Try raising the head of your bed about 4 inches with blocks. It might also help to avoid eating or drinking for 2 hours before your husband lie down. To help control the stomach acid , one should not drink alcohol or drinks with caffeine in them or eat chocolates or spicy or greasy foods. Also take some antacid ( with ingredients oxetacain in them). As symptoms are very severe so proton pump inhibitor may require. 2 You mentioned that there is diverticulosis . In my opinion this is not a case of diverticulosis. The symptoms of diverticulosis are distension, flatulence & sensation of heaviness in the LOWER abdomen ( as all these symptoms are not present ) 3 The most important reason of this pain is tension & anxiety . Diagnosis can be confirmed with the help of a psychiatrist . In my opinion simultaneously consult a psychiatrist /gastroenterologist and get their opinion. Good luck for your husband. Dr. HET