Hi and thanks for the query, it might be necessary to consult your physician. Pregnyl could be very useful to your wife at this point in time. The degree of swelling is important to be noted. It s very important to distinguish this from an allergy. Actually linking this swelling to this drug is important. If the symptoms are however very mild, considering the fact this drug is very important in order to avoid any potential miscarriage, you might have to be patient and manage the symptoms since they shall not take long. I suggest you consult your physician for advice. Thanks and best regards, Luchuo, MD.