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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Pregnant From Frozen IVF Embryo. Did Nuchal Translucency Test, Ultrasound. Can Online Doctor Help?

Dear Doctor,
I am 40 years old and currently 12 weeks and 1 day pregnant from a frozen IVF embryo. I had my Nuchal Transluncy test today and received the following results:
NT = 2.1 mm
FB hCG = 3.78 MOM
PAPP-A = 0.55 MOM
Ultrasound was perfect with nasal bone present, good growth of organs and blood flow etc
They said I had a 1 in 8 percent chance of Down Syndrome. How much reliance should I put on the blood test? Is my risk 'artificially inflated' due to my age? I had a healthy son naturally in 2010 when I was 37 and the numbers were:
NT = 1.8mm
FB hCG = 1.84 MOM
PAPP-A = 0.90 MOM.
What does a high FB hCG and low PAPP-A mean? At what level is a FB hcG considered high and a PAPP-A considered low?
Thanks for your help.

Mon, 13 May 2013
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OBGYN,  's  Response
Hello, I would be happy to help you with your question.

When you state "1 in 8" percent chance of Down's, you are implying that there is a 12.5% chance of a Down's pregnancy. It does not seem possible that this could be the final result of the entire screen. Are you saying this based on a lab value alone?? The first trimester screen involves a calculation that includes Papp-A, free beta-HCG, and the nuchal translucency. They are not usually looked at individually. Of the beta-HCG and Papp-A levels, the only one with true clinical relevance on its own is the Papp-A. In patients where it is
I hope that this helps. If you have more questions, please click on "ASK ME A QUESTION" link above to directly ask me a question!
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Pregnant From Frozen IVF Embryo. Did Nuchal Translucency Test, Ultrasound. Can Online Doctor Help?

Hello, I would be happy to help you with your question. When you state 1 in 8 percent chance of Down s, you are implying that there is a 12.5% chance of a Down s pregnancy. It does not seem possible that this could be the final result of the entire screen. Are you saying this based on a lab value alone?? The first trimester screen involves a calculation that includes Papp-A, free beta-HCG, and the nuchal translucency. They are not usually looked at individually. Of the beta-HCG and Papp-A levels, the only one with true clinical relevance on its own is the Papp-A. In patients where it is I hope that this helps. If you have more questions, please click on ASK ME A QUESTION link above to directly ask me a question!