Glanzmann's thrombasthenia is an autosomal recessive, inherited platelet function disorder
. There is an absence of glycoprotein (GP) IIb/IIIa on the platelet membrane which causes reduced platelet aggregation with a defective platelet haemostatic plug formation.Pregnancy and delivery is rare in these patients and is associated with a high risk of severe haemorrhage
1-Once pregnancy occurs, patients
may develop bleeding during pregnancy
obstetric causes, intrapartum or postpartum
2-Pregnancy in patients with Glanzmann's
thrombasthenia is rare,
but it is life-threatening
for both the patient and her fetus.
The fetal risk
is related to fetal immune thrombocytopenia
induced by the transplacental passage of the
maternal IgG anti-GPIIb-IIIa isoantibodies, In
case of the severe fetal thrombocytopenia, there
is a risk of fetal intracranial hemorrhage
3-A team work, the obstetrician and the
is essential in deciding the best
option and best time to interfere in this high- risk
group of patients.
so mr pithabas better take consultation of both gynecologist and hematologist.