Hi, Taking progesterone and aspirin during pregnancy is a common practice to prevent miscarriage or other pregnancy complications, but it should be done under the supervision of a healthcare provider. Both medications have potential risks and benefits that need to be weighed carefully before deciding to take them. Progesterone is a hormone that plays a crucial role in maintaining pregnancy. It helps to thicken the lining of the uterus, which provides a suitable environment for the fertilized egg to implant and grow. Progesterone supplementation is often recommended for women who have a history of miscarriage or who are at risk of preterm labor. Duphaston is a brand of progesterone that is commonly used for this purpose. Aspirin is a medication that can help to prevent blood clots and improve blood flow. It is sometimes recommended for pregnant women who are at high risk of preeclampsia, a potentially life-threatening condition that can cause high blood pressure and damage to organs such as the kidneys and liver. Aspimed 75 is a brand of aspirin that is commonly used for this purpose. It is important to note that both progesterone and aspirin have potential risks and side effects. Progesterone supplementation can cause symptoms such as nausea, dizziness, and headaches, while aspirin can cause stomach upset, bleeding, and other side effects. It is important to discuss any concerns or side effects with your healthcare provider and to follow their instructions carefully. In summary, taking progesterone and aspirin during pregnancy can be safe and beneficial in certain cases, but it should always be done under the guidance of a healthcare provider. It is important to discuss any potential risks or concerns with your healthcare provider and to follow their instructions carefully. If you require a personalized response, kindly use the Ask A Doctor service and post a follow-up. Take care. Hope I have answered your question. Regards, Dr. Priyanka, General & Family Physician