Hello Sir, and I hope I can help you today Ceftum is a kind of antibiotic that is a cousin of penicillin, and can be safely taken during pregnancy as can all penicillin-based antibiotics. So you do not need to worry about your wife s pregnancy from the medication the doctor prescribed. However, to properly treat a urine infection the dosing of the medication is typically 500 mg three or four times daily rather than just twice. If your wife completes the medication and her next urine test still shows white blood cells (plus) it should be cultured for bacteria to make sure that the infection is gone, because this dose of septum is frequently not strong enough to properly treat the infection, even in a pregnant woman. So in summary, it certainly is safe to take the prescribed medication for your wife during the pregnancy, and her doctor should consider increasing the dose if the suspected urine infection does not resolve within a few days. I hope that I was adequately able to answer your question today, and that this information was helpful. Best wishes, Dr. Brown