Dear Doctor, I am 34 years old male and have Thalassemia (minor). My wife is 31 years old and she does not have Thalassemia. Both of us have done Karyotyping Tests. In my Karyotyping Tests it is mentioned as normal. And in wife’s report it is mentioned as “Chromosomal analysis (GTG Banding with 500 band resolution) revealed female karyotype with increase in the length of heterochromatin region of long arm of chromosome 9 i.e. 46, XX, 9qh+ pattern in all the cells analysed. This is a polymorphic variant which will not have any clinical significance. Genetic counseling is recommended. ”We had a baby son (first child) with Trisomy 21, who had an open heart surgery for “Atrioventricular Septal Defect with Common Atrioventricular Valve”. We lost him at the age of 6 months. Considering our past history, request you to please let us know whether there is any issue of concern. Is it safe to plan for another baby? Kindly guide and advice us. We will be ever thankful to you for your kind help. Anxiously waiting for your reply.