Hello. Welcome to HCM. Like elsewhere in the body, brain too can be affected by a granulomatous reaction, commonly 1. Tuberculosis 2. Fungal infections 3. sarcoidosis. 4. Cysticercosis 5. Uncommon causes- cholesterol granulomas, angitis related or Wegener s granulomatosis can also involve brain. Each of these granulomas have specifc morphological clues, pointing out to its etiology. Once, the cause is decided, treatment can be targeted towards that cause. Depending on site in brain and extent of involvement of brain tissue, the clinical features may be seizures, personality changes, simply headache, visual defects- to name a few. Mostly if the granulomas are located in the cerebral cortex (commonly frontal hemisphere), the patient will present as seizures. Hope this helps.