Hi & Welcome. It is not safe to consume alcohol or alcohol containing beverages while taking Diflucan. Diflucan (Fluconazole) can produce the so-called “disulfiram like reaction” when taken along with alcohol. Disulfiram, or antabuse, is a drug that treats alcoholism by making the person acutely sensitive to alcohol. When he drinks alcohol while there is disulfiram in his system, he experiences very unpleasant symptoms such as anxiety, restlessness, high BP, severe nausea, vomiting, throbbing headaches, shortness of breath, mental confusion, skin flushing, & visual impairment. This is referred to as “disulfiram reaction” Diflucan is also known to cause or aggravate liver damage, similarly alcohol is also harmful to the liver. Thus, taken together, they can cause more damage to the liver. So, avoid taking alcohol or alcohol containing beverages as long as you are treated with Diflucan and thereafter also. Hope this will help you. A feed back is highly appreciated.