Hi, It is not safe to take Oxyelite while on Zoloft. Oxyelite-pro contains an antidepressant fluoxetine. Fluoxetine is a selective serotonin re-uptake inhibitor commonly prescribed for treatment of depression, bulimia, obsessive-compulsive disorder, and other conditions. Taking fluoxetine while on sertraline can increase the risk of cardiac arrhythmia (irregular heart rhythm) that may be serious and potentially life-threatening. You may be more susceptible if you have a heart condition called congenital long QT syndrome, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). In view of the above, it is better to avoid taking Oxyelite while on Zoloft. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Mohammed Taher Ali, General & Family Physician