Dear friend, welcome to Healthcaremagic! I am Dr. Prasad Akole (Critical Care Expert- http://bit.ly/Dr-Prasad-Akole) and am glad to address to your query here. No. it is not due to Benadryl. You have an allergenic reaction and Benadryl has anti-allergic properties. It helped and now the symptoms have appeared due to disappearance of Benadryl from the system. If you have breathing difficulty, giddiness, spreading hives or redness, cough, please go to ER/ doctor to rule out serious signs like low BP or bronchospasm. Oral non-sedating anti-allergics and steroids would suffice the minor symptoms. Benadryl can cause drowsiness, so 3 a day dosing may not be possible for a working person. Oral fexofenadine and prednisolone may be had under medical supervision. Benadryl is OK till then (do not drive with it in). local creame is not very useful. Try to find out and avoid what is causing it. I hope to have answered your query satisfactorily. I would be glad to answer any further queries. Take care and please keep me informed of your progress at http://bit.ly/Dr-Prasad-Akole Good Luck! It helps us to improve continuously if you could please write a rating review before you ‘accept’ and ‘close’ the query. Thank you!!