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Glomerular filtration rate as calculated on a standard laboratory panel now utilizes a formula known as MDRD. Since the advent of this formula and its use as the primary method of calculation of GFR on standard laboratory panels, there has been a more precise determination of GFR without a 24-hour urine collection. Despite its increased accuracy, there are a few caveats in its interpretation. For example extremes of body weight and age do not yield accurate results. Furthermore there is a 10% decline in GFR per decade after the age of 30-40. In order to determine if there is a clinically relevant reduction in renal function or kidney
disease for that matter, a urinalysis
, evaluation of urine protein, renal ultrasound
and serial creatinine
assessments would be required at minimum.
Should you want to simply answer your question of whether or not your GFR has declined from normal, all that is required is a 24-hour urine collection for creatinine clearance.
Take care and be well