dear sir I can understand your concern the medication cholesteoff is a natural plant product extracted from pine tree in my opinion the medication Januvia is responsible for lowering of your blood sugar but a minor contribution can be expected from cholesteroff. in our body due to excess of cholesterol content the insulin will fail to work properly. in some individuals this resistence for insulin can be reduced to certain extent by reducing cholesterol content of body I suggest you can continue taking both medications and follow good diet and exercise for better results keep checking your cholesterol at regular interveks as suggest by your doc regards