Hi, Cetirizine is an antihistamine commonly used to relieve allergy symptoms such as itching, sneezing, and runny nose. While eye twitching is not a commonly reported side effect of cetirizine, individual responses to medications can vary, and rare side effects are always possible. In some cases, antihistamines can cause side effects that affect the nervous system, such as drowsiness or dizziness. Eye twitching, also known as eyelid myoclonus or eyelid fasciculation, is a muscle contraction of the eyelid that can occur due to various reasons, including stress, fatigue, caffeine, and certain medications. If you have noticed that your eye twitching coincided with starting cetirizine and that it stopped after discontinuing the medication, it s possible that there could be a connection. However, it s also important to consider other factors that may contribute to eye twitching, such as stress, fatigue, or other underlying conditions. If you have concerns about cetirizine or any other medication you are taking, it s always best to consult with your healthcare provider. They can review your medical history, evaluate your symptoms, and provide personalized advice. They may suggest alternative medications or adjustments to your allergy treatment plan address your symptoms effectively while minimizing side effects. Remember, the information provided here is for general purposes only and should not replace professional medical advice. Your healthcare provider is the best resource to address your specific concerns. If you require a personalized response, kindly use the Ask A Doctor service and post a follow-up. Take care. Hope I have answered your question. Regards, Dr. Priyanka, General & Family Physician