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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Lamotrigine Cause Elevation Of Dilantin Levels In The Blood?

Taking 500 MG Lamotrigine with 350 MG Dilantin. Have been told by neurologist that my Dilantin blood levels Have increased (16 to 21) due to the addition of the Lamotrigine. Have not been able to verify this with any other source. Does this sound correct?
Mon, 13 Aug 2018
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General & Family Physician 's  Response
Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice.

As per the clinical data base, Dilantin (Phenytoin) may decrease the blood level and efficacy of Lamotrigine; but other is not documented. But still, anything can be possible depending upon the individual characteristics, which is a matter of detailed case analysis by sequential analysis on data base. Take care.

Hope I have answered your query. Let me know if I can assist you further.
Regards,     
Dr. Purva Patel
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Does Lamotrigine Cause Elevation Of Dilantin Levels In The Blood?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. As per the clinical data base, Dilantin (Phenytoin) may decrease the blood level and efficacy of Lamotrigine; but other is not documented. But still, anything can be possible depending upon the individual characteristics, which is a matter of detailed case analysis by sequential analysis on data base. Take care. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Purva Patel