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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Does Cyclobenzaprine Interact With Oxycodone?

I am 4 weeks post op Lt total knee surgery. I take a 5 mg oxycodone for pain before sleep and another 5 mg tablet no sooner than 4 hrs later if needed for pain. My quad has tightened up and has become tighter as the day wears on. Would it be safe to take a 10 mg cyclobenzaprine(flexeril) to see if it helps. I have a physical therapy appt in the AM.
Thu, 19 May 2016
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General & Family Physician 's  Response
HI
It should be safe to take the Flexeril but if you take both that and an oxycodone close together it may make you drowsy
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Does Cyclobenzaprine Interact With Oxycodone?

HI It should be safe to take the Flexeril but if you take both that and an oxycodone close together it may make you drowsy