Hi, Azithromycin is an antibiotic commonly used to treat a variety of bacterial infections, including skin infections. It is generally well-tolerated, but like all medications, it can cause side effects in some people. Headaches are a known side effect of azithromycin, and some people may also experience changes in mood or feelings of irritability. Diarrhea is also a possible side effect of azithromycin, and it can be a sign of an intestinal infection called Clostridioides difficile (C. diff), which can be a serious complication. If you have severe or persistent diarrhea, you should contact your doctor. In general, most people tolerate azithromycin well and do not experience significant side effects. However, if you are experiencing bothersome symptoms or have concerns about how the medication is affecting you, you should speak with your doctor. They may be able to recommend alternative treatments or adjust your dosage to help minimize side effects. If you require a personalized response, kindly use the Ask A Doctor service and post a follow-up. Take care. Hope I have answered your question. Regards, Dr. Priyanka, General & Family Physician