Hi! Thanks for your query. Dear sir, Methotrexate and steroids form the sheet anchor of treatment for SLE. Azathioprine is a steroid sparing agent . Since you have been started on these three medications , that means that disease activity is high . These medicines have their own side effects on almost every organ of body but considering the disease you suffer from it is definitely important to continue these medications . SLE itself can lead to heart problems like pericardial effusion . You should get your routine blood tests Like CBC, liver function tests , renal function tests while on these medications and be in constant touch with your rheumatologist for regular assessment .I also advise you to get your calcium levels checked as recent studies claim that excessive calcium deposition can lead to atherosclerosis. Wish you a good health. Take care. Dr. Shruti.