Hello, - Restless legs syndrome is commonly seen in patients with cancer. However, I could not find any academic literature linking it with radiation therapy - Its usually experienced in both lower legs with the following: -- You have a strong, often irresistible urge to move your legs, usually accompanied by uncomfortable sensations -- Your symptoms start or get worse when you re resting, such as sitting or lying down -- Your symptoms are partially or temporarily relieved by activity, such as walking or stretching -- Your symptoms are worse at night -- Symptoms can t be explained solely by another medical or behavioral condition - There are several medicines that are known to help with this like Ropinirole, Pramiprexole, etc., that you can discuss with your doctor. Some things your husband can try at home are: -- Cold packs -- warm baths and massages -- Good sleep hygiene -- Avoid caffeine -- Exercise Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Pranav Balakrishnan, General & Family Physician