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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Regular Intake Of Gardinal Syrup Cause Increased GGT Level?

Please find a comparison of last five LFT Test results below: - LFT TEST ON 2.05.2011 Bilrubin Total - 0.9 mg/dl [Conjugated 0.3 mg/dl, Unconjugated 0.6 mg/dl] Total Protein - 5.4 g/dl Albumin - 2.3 g/dl Globulin - 3.1 g/dl SGOT - 77 U/L SGPT - 33 U/L Alkaline Phosphatase - 428 U/L Gamma GT - 397 U/L LFT TEST ON 25.03.2011 Bilrubin Total - 3.7 mg/dl [Conjugated 2.3 mg/dl, Unconjugated 1.4 mg/dl] Total Protein - 5.3 g/dl Albumin - 3.3 g/dl Globulin - 2.0 g/dl SGOT - 140 U/L SGPT - 58 U/L Alkaline Phosphatase - 600 U/L Gamma GT - 220 U/L LFT TEST ON 25.02.2011 Bilrubin Total - 6.9 mg/dl [Conjugated 6.0 mg/dl, Unconjugated 0.9 mg/dl] Total Protein - 5.8 g/dl Albumin - 3.0 g/dl Globulin - 2.8 g/dl SGOT - 376 U/L SGPT - 114 U/L Alkaline Phosphatase - 661 U/L Gamma GT - 80 U/L LFT TEST ON 17.02.2011 Bilrubin Total - 11.4 mg/dl [Conjugated 9.47 mg/dl, Unconjugated 1.93 mg/dl] Total Protein - 4.8 g/dl Albumin - 2.0 g/dl Globulin - 2.8 g/dl SGOT - 369 U/L SGPT - 269 U/L Alkaline Phosphatase - 835 U/L Gamma GT - 92 U/L LFT TEST ON 11.02.2011 Bilrubin Total - 15.0 mg/dl [Conjugated 12.95 mg/dl, Unconjugated 2.05 mg/dl] Total Protein - 4.8 g/dl Albumin - 2.5 g/dl Globulin - 2.3 g/dl SGOT - 583 U/L SGPT - 326 U/L Alkaline Phosphatase - 634 U/L Gamma GT - 72 U/L As per the reports provided to me from the various lab the normal values for neonates is as under - RANGE FOR NEONATES Bilrubin Total - 1 to 10.5 mg/dl [Conjugated 0 to 0.6 mg/dl, Unconjugated 0.6 to 10.5 mg/dl] Total Protein - 6.3 to 8.2 g/dl Albumin - 3.5 to 5.0 g/dl Globulin - 2.3 to 3.5 g/dl SGOT - 17 to 59 U/L SGPT - 21 to 72 U/L Alkaline Phosphatase - Not given in any report as per information in internet for neonates it can be up to 800 U/L Gamma GT - Not given in any report as per information in internet for neonates it can be up to 5 to 9 times of the adults nonmal range. The normal range for adult is from 15 to 73 U/L ---------------------------------- My baby has shown tremendous improvement after i had started the treatment at Appolo. Earlier the diagnosis was indicative of either Neonatal Hapatitis or Atresia. Now after three and half months treatment Bilrubin is completely within the range and SGOT and SGPT values are also fairly within the range. My worry is w.r.t GGT which is showing increasing trend fro 72 (on 11.02.2011) to 397 (on 2.05.2011). My baby is properly taking mother s feed and colour of his stool is also yellow. His birth weight was 2.07 Kg and now he has gained weight of about 5.080 kg. No other abnormality or abnormal behavior has been reported. I have gone through the net and got an literature about GGT that it can also increase after intake of phenobarbitone. Since February by baby is daily getting Gardinal Syrup twice a day, can this be a reason for increased GGT? Doctor Here at Dehradun has told that the size of liver and spleen is slightly large. Kindly give me the cause and suggest further.
Wed, 30 Nov 2016
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Pediatrician 's  Response
Yes, Phenobarbitone can cause increased GGT levels. GGT is a marker of synthetic function of the liver. Please see a paediatrician to decide on change of drug.
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Can Regular Intake Of Gardinal Syrup Cause Increased GGT Level?

Yes, Phenobarbitone can cause increased GGT levels. GGT is a marker of synthetic function of the liver. Please see a paediatrician to decide on change of drug.