Hello, I understand and appreciate your question. Brief Answer: No, Vistaril does not cause the feeling of dry eye . But Systane and Restasisis plus can cause an eye unpleasant feeling . Detailed Answer: Vistaril is used to treat itching caused by allergies. It may also be used short-term to treat anxiety or to help you feel sleepy/relaxed before and after surgery. Side effects are: Drowsiness, dizziness, blurred vision, constipation, dry mouth mental/mood changes (such as restlessness, confusion, hallucinations), shaking, difficulty urinating. When Systane is first used vision may be temporarily blurred . Also,eye pain, change in vision, continued eye redness/irritation. Side effects Restasis plus are: eye pain; or eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection), mild burning or stinging in the eyes; mild redness or itching; blurred vision; or feeling like something is in your eye. Please contact your doctor to take other medication. Thank you for asking your query on health care magic. If you have more questions, feel free to ask. Thank you. Kind regards.