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Can A Vitamin-k Shot Be Taken By Carrier Of Alpha-1 Antitrypsin Deficiency?
I am a carrier for Alpha-1 antitrypsin deficiency, and may be a carrier for G6PD deficiency (I know my mother is a carrier, but I have never been tested). I am currently pregnant with a son who could inherit these traits from me and am wondering if I should or shouldn t allow him to receive a vitamin K shot at birth. I know there are interactions with G6PD deficiency if I do allow the vitamin K shot (both my brother and my cousin s son have the deficiency, both received vitamin K shots at birth, and both had serious health complications as a result). However, I m also aware that infants with Alpha-1 antitrypsin deficiency are at an increased risk for hemorrhagic disease of the newborn (HDN) if they do not receive a vitamin K shot. I am wondering which is a greater risk and what the best decision would be: vitamin K shot or no vitamin K shot.
Mon, 28 Nov 2016
Dear Madam, Hi & Welcome.
I have gone through your history and I am of the opinion that Vitamin K1 injection can be given to a carrier of alpha-1 antitrypsin deficiency safely.
While vitamin K deficiency is very common in newborn infants and the low levels of vitamin K can raise the risk of uncontrolled bleeding including the serious intracranial bleeding.
As per the American Academy of Pediatrics a single intramuscular dose of vitamin K1 (Phytonadione) be given to the newborn within one hour. This is to prevent vitamin K dependent bleeding complications like intracranial bleeding which can be life threatening in alpha-1 antitrypsin deficiency patients especially in the neonatal period.
As far as the G6PD deficiency is concerned, larger doses of vitamin K3 (Menadione) can cause harmful effects. However, in G6PD deficient infants there are no reports of hemolysis or other toxic effects if vitamin K1 (Phytonadione) is given in neonates.
So, in view of the above vitamin K1 can be given safely to your new born baby to prevent serious complications of bleeding due to vitamin K deficiency.
Hope these answer your queries.
Best wishes.
I have gone through your history and I am of the opinion that Vitamin K1 injection can be given to a carrier of alpha-1 antitrypsin deficiency safely.
While vitamin K deficiency is very common in newborn infants and the low levels of vitamin K can raise the risk of uncontrolled bleeding including the serious intracranial bleeding.
As per the American Academy of Pediatrics a single intramuscular dose of vitamin K1 (Phytonadione) be given to the newborn within one hour. This is to prevent vitamin K dependent bleeding complications like intracranial bleeding which can be life threatening in alpha-1 antitrypsin deficiency patients especially in the neonatal period.
As far as the G6PD deficiency is concerned, larger doses of vitamin K3 (Menadione) can cause harmful effects. However, in G6PD deficient infants there are no reports of hemolysis or other toxic effects if vitamin K1 (Phytonadione) is given in neonates.
So, in view of the above vitamin K1 can be given safely to your new born baby to prevent serious complications of bleeding due to vitamin K deficiency.
Hope these answer your queries.
Best wishes.
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