Hi, welcome to our site. I am Dr Saumya Mittal, MD. Read your query. That is a very significant question and i appreciate your problem. I will try my best to answer your query First, ciplox will not cause the headache. The headache may be due to the other reasons, related to your meningoencephalitis. In fact, headache is one of the main features of the meningoencephalitis- or brain infection in simple words. I am assuming, your doctor has not met you since the development of this headache. I would have suggested an MRI brain, and possibly a repeat lumbar puncture to see if the infection was improving. You may take some paracetamol for this headache. As I said, its a part of the infection syndrome and will improve as the infection settles. The treatment length depends on the type of infection. As from the information provided, I am not sure about the type of bacteria. Please let me know the type of bacteria so i can inform you the duration needed I hope this helps you. Inform the reports mentioned above/if any other so I can be of help further. I have given you the answer to the maximum considering the information provided. The results of the tests could further enhance my answer to you. Please do understand that some details could be extracted from a detailed history and examination. Please feel free to ask another query. I would be glad to help you. Looking forward to your return query with the details asked so that I can help you further. (If the answer has helped you, please indicate this) Best of luck. Dr Mittal. MBBS, MD (Internal Medicine), CC (Diabetes Mellitus), DNB (Neurology) Consultant Physician and Diabetologist JS Hospital Ex Apollo Hospital, Delhi Ex Kailash Hospital, Noida