Hello and welcome to HCM First I would like to give you some information regarding the Parkinsons disease and its treatment. Parkinsons is a neurodegenerative disease . It is characterised by degeneration of nerve cells in the brain which release a chemical called dopamine . Deficiency of this chemical is responsible for the symptoms of Parkinson s disease like regedity, tremors, defective posture, defective gait, mask like face, , increased salivation etc. dementia (forgetfullness) and depression often accompany. The treatment of Parkinson s disease aims to repelinsh the decreased chemical dopamine in the brain. For this purpose sndopa is used (levodopa). Sndopa also contains carbidopa. However this drug has not be used alone. It has to be given along with Vitamin B6 and a substance with inhibits the break down of sndopa in body before it reaches the brain. This drug is called carbidopa. This substance is present in sndopa. Please ensure vitamin B 6 supplement is used along with sndopa. The symptoms that you have mentioned mean that your grandmother is not responding to the treatment. She having depressive symptoms which are associated with disease itself, may be associated with the disease (chronic diseases are associated with depression) or depression in isolation. Side effects od sndopa are nausea, disturebed respiration, GI bleeding, somnolence (increased sleep), insomnia, hair loss, psychosis etc. Consult your treating physician as well as a psychiatrist. Thanks and take care Dr Shailja P Wahal