Hello! After going through a detailed review of your discussion, I would like to comment on the condition -- 1) The significantly raised liver function parameters in a 30 weeks pregnancy suggest a poor & grave outcome. 2) However, I would like to suggest you to hospitalize the patient immediately to have a multidisciplinary management. She requires to be observed by a team of specialists containing an eminent gynecologist, a gastroenterologist, a general physician, an oncologist & an intensive care expert. 3) The Itching associated with a significant rise in the hepatic functional parameters is generally considered to be a manifestation of Obstructive Jaundice , which is many times a potentially lethal condition & may be associated with or a symptom of malignancy & may require surgery, but in this case seems to be a very complicated situation to manage. Thanks & wishing a good recovery of your wife!