Question: Orthopaedic question: Doctor my wife is 64 year old with diabetes since 10 years and hypothyroidism since 3 years. Of late she is getting pain on the right leg near the left side of the knee (marked with red marker for reference) .The pain increases particularly when she sleeps in the night. She had this pain in the year 2009 also . The then attending Ortho has prescribed Ace proxivon 1 sos. Later it subsided. Now again we went to a Ortho who has taken PA and lateral views of the right knee. He tested her C-reactive protein which is 6.4 ,he has prescribed Aceclodol MR 1bd for 10 days and prescribed stamina OD and ostium k2, chlorocalciferal one XXXXXXX a week for 4 weeks. She has, prior to the visit to ortho , she has taken acelo 1bd for4 days and then Ace proxivon 1 bd for 3 days.she has completed taking Aceclodol MR and taking the other three medicines. Initially for about 3 or 4 days the pain subsided. Later the pain started again particularly in the night. There is no inflammation outside or swelling . Is this osteo arthritis or what do you call this condition.She has no heridity in Arthritis in her family..what is the remedy.?what is the safest pain killer for this knee pain?. Can she continue for another round of pain killer? Is it safe? kindly enlighten me on all my questions.

Doctor ,thank you very much for your advise. Can she take Nac 150 sr instead of Acelodol MR. If so can she take it sos or every day during the night .Kindly advise me the dosage, .thank you sir.Her thyrodi level is right now is 2.5