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Many drugs can affect serotonin levels in the body. Alcohol, nicotine and marijuana cause a burst in the release of serotonin by your neurons, resulting in an initially elevated euphoric mood. However, once the initial feeling of euphoria fades, serotonin levels drop lower than they were originally, a significant serotonin depletion. Often, this leads to continued drinking or smoking in a futile effort to regain the initially heightened serotonin levels.

The person who has used marijuana for longer time, their histamine levels are extremely low.

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