Question: You gave me an explanation (which I just discovered) regarding MENEST, but really did NOT answer my question. THIS SITE suggested taking PROLIA. I have many issues: Jaw bone problems (2 Dental Surgeon have suggested I be careful when taking medications for bone loss. [Inoperable Wisdom tooth growing into my jaw bone; 2 dentists, and two different oral surgeons WON'T touch it as the roots have infiltrated my lower jaw, which is quite fragile] Have Osteopenia for which I've taken Menest for years. Each year, my Bone Density test indicates that I am still in the category of "Osteopenia" (latest in 2016), and has remained at that level for at least 15 years. My now retired Rheumatologist suggested taking it into my 80's to prevent Osteoporosis. I've 4 inches in height. I take Coumadin for minor stroke that was a result of Migraines after short term exposure to Propane in portable heater---allergic episode. The stroke affected my vision, reducing my field of vision to 25% for several years. Field was regained up to 75%--25% permanent loss. I am monitored by weekly to monthly at a Coumadin Clinic. No problems, except for last summer. My Primary Care doc gave me Crestor. I had severe reaction (as has happened with a number of newer synthetic drugs). I was treated by ER and told to stop taking Crestor, which is supposedly the least likely to cause reactions. I do NOT well tolerate many newer class medications, as has been discovered over time. My Allergist has cautioned me about taking new class meds. My PC does not listen. Became somewhat arrogant and stubborn while I was reviewing my medical history with him. He dismissed reasons for not taking some of the meds he as prescribed over time even though on 2 different occasions I've gone to the ER due to reactions. So, after with regard to my medical conditions (severe seasonal and chemical allergies, well-managed stroke therapy after stroke 19 years ago, Sinus issues, spinal ablation of L4-L5, broken bones in foot, and recently, tail bone fracture), WHY would my Rheumatologisthave insisted that continuing with Menest is the least problematic option for me? He told me not to take Boniva. In fact he steered me away from those bone building meds because of the possibility of hip and femur fractures and breaks. I have never had a problem with MENEST and because of that medication my bone density has remained at the OsteoPenia level for years. Maybe Menest isn't helping much, I don't know. All I know is that my condition has remained at the OsteoPenia level for at least 10+ years. I also have knee, hip, shoulder, neck and hand arthritis. When I've taken medications that I cannot tolerate (such as Crestor, Zocor, Lipitor), I also develop skin rashes. Once took Premarin (low dose) when Menest wasn't manufactured for a time. Once back on it, everything stablized. So why should I mess around and introduce into my body a new, unknown entity that could potentially cause problems? These bone drugs seem to have a lot of problems. I take many medications already: Combo Vasotec & Procardia--for Raynaud's disease; hydroxizine-- for allergy; Metformin--Type 2 Diabetes; Warfarin 7 mg daily--closely monitored; synthroid--hypothroidism. Would appreciate it if you might review this again.