Brief Answer:
HIV and HIV testing
Detailed Answer:
Hi,
Thanks for choosing health care magic for your query.
Before I answer your queries I want to elaborate on few details regarding HIV for better understanding.
HIV is Human
Immunodeficiency Virus and it causes a condition called as AIDS which is Acquired Immunodeficiency syndrome.
The commonest mode of spread of HIV is sexual intercourse (Vaginal, anal, or oral) with HIV infected individual.
The other modes include sharing of contaminated needles during
drug abuse and through
blood transfusion.
HIV positive mother can give the virus to her fetus during delivery or while breast feeding.
HIV gains entry into the body through the mucosa lining the genitals and multiplies in the local lymph nodes, It then spills into the blood after 4-11 days. So technically there is no test that can detect the HIV within 4 days of exposure.
Antibodies against HIV appear in the blood 3-12 weeks after exposure. The period from exposure to appearance of antibodies is called window period. This window period is variable in different individuals.
Now coming to your questions:
1. Symptoms of HIV: HIV can be divided into 4 groups based on the symptoms and time since exposure.
Group 1 - acute primary HIV infection – fever, lethargy, joint pain,
skin rash,
lymphadenopathy (mild). Rarely mucocutaneous ulcers and
depression. (first 2 weeks)
Group 2 - asymptomatic (1 year after exposure)
Group 3 - persistent generalized lymphadenopathy (1-3 years)
Group 4 - AIDS related complex (after 5 years)
Progression of disease varies in different individuals.
2. Based on the time of exposure, the best tests are mentioned below:
Early exposure: Best tests would be p24 antigen and PCR for HIV RNA.
After 12 weeks: ELISA for HIV 1 and 2 antigens and antibodies, western blot test.
3. I have mentioned the best tests based on time since exposure above.
I hope I have cleared all your doubts.
Please get back for any more clarifications.
Thanks.