Sign-in to Ask A Doctor - 24x7
OR
Sign in with Google
What Does This Blood Report Indicate?
Question: My Wife is Pregnant and did NT at 10 week 5 days -1.5 mm thickness and CRL is 34.5 mm and same day did blood test .PAPP-A value -3.8 mIU/ml and free B HCG is 121 ng/ml . Her weight is 48 Kg , Height -152 cm LMP is 19/09/2015 and Bate of birth 02/12/1981 . her Race is Asian , No smoking habit and No Diabetics . Please give risk of Trisomy 21and Trisomy 13/18.
Brief Answer:
Please attach report copy providing MoM values of PAPP-A and free beta HCG
Detailed Answer:
Hi XXXX,
Thanks for writing in to us.
I have read through your query in detail.
Please find my observations below.
1. The values of PAPP-A and free beta HCG are required in MoM (multiples of median) which is probably mentioned in the report. MoM values are obtained after considering race, ethnicity, age, weight and smoking status. It should be mentioned in the report.
2. This is because PAPP-A and free beta HCG is not a constant and changes with age of pregnancy.
3. Calculation of risk for Trisomy 21 and 18-13 requires the MoM values of PAPP-A and free beta HCG along with the other mentioned details like age (34 years), NT (1.5 mm) and CRL (34.5 mm)
Please attach a copy of the report to your query and send in a follow up. I will reply back after making the calculations.
Regards,
Please attach report copy providing MoM values of PAPP-A and free beta HCG
Detailed Answer:
Hi XXXX,
Thanks for writing in to us.
I have read through your query in detail.
Please find my observations below.
1. The values of PAPP-A and free beta HCG are required in MoM (multiples of median) which is probably mentioned in the report. MoM values are obtained after considering race, ethnicity, age, weight and smoking status. It should be mentioned in the report.
2. This is because PAPP-A and free beta HCG is not a constant and changes with age of pregnancy.
3. Calculation of risk for Trisomy 21 and 18-13 requires the MoM values of PAPP-A and free beta HCG along with the other mentioned details like age (34 years), NT (1.5 mm) and CRL (34.5 mm)
Please attach a copy of the report to your query and send in a follow up. I will reply back after making the calculations.
Regards,
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Brief Answer:
The risk is relatively low
Detailed Answer:
Hi XXXX,
Thanks for writing back with an update.
1. The risk of trisomy 21 is approximately 1 in 1400
2. The risk of trisomy 18-13 is approximately 1 in 100000
3. In my opinion the risk is less and you can discuss this with your doctor.
Regards,
The risk is relatively low
Detailed Answer:
Hi XXXX,
Thanks for writing back with an update.
1. The risk of trisomy 21 is approximately 1 in 1400
2. The risk of trisomy 18-13 is approximately 1 in 100000
3. In my opinion the risk is less and you can discuss this with your doctor.
Regards,
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
This result is combined with NT scan and blood test?
Some people tell me usually NT scan do at 11 week to 13 week and CRL 45 mm to 84 mm . but my doctor did 10 week 5 days . is it accurate ?
Some people tell me usually NT scan do at 11 week to 13 week and CRL 45 mm to 84 mm . but my doctor did 10 week 5 days . is it accurate ?
Brief Answer:
The result combines NT scan and blood test
Detailed Answer:
Hi XXXX,
Thanks for writing back with an update.
1. In the above calculation the NT scan is combined with blood test and is more accurate than NT scan alone.
2. NT scan is to look for the thcikness behind the neck and is done from 10 - 11 weeks to 14-15 weeks. I usually do NT scan at 11 - 12 weeks for my patients.
3. Since the age is 10 weeks 5 days therefore I consider it nearly 11 weeks and not a problem.
4. Coming to CRL, a value of 40 mm and above is used by most doctors when calculating risk but in your case NT is normal therefore CRL was not used to make the calculation.
5. In your case, the value of PAPP-A and free beta HCG blood test is on normal side, therefore there is below average risk. Please remember that these tests are providing risks only. Higher invasive tests are done only if the basic tests show high risk and this is done in genetic clinics from 16 to 19 weeks of gestation in most cases. Therefore any basic test is not 100 percent accurate but most likely acceptable.
Hope your query is answered.
Please do write back if you have any doubts.
Regards,
The result combines NT scan and blood test
Detailed Answer:
Hi XXXX,
Thanks for writing back with an update.
1. In the above calculation the NT scan is combined with blood test and is more accurate than NT scan alone.
2. NT scan is to look for the thcikness behind the neck and is done from 10 - 11 weeks to 14-15 weeks. I usually do NT scan at 11 - 12 weeks for my patients.
3. Since the age is 10 weeks 5 days therefore I consider it nearly 11 weeks and not a problem.
4. Coming to CRL, a value of 40 mm and above is used by most doctors when calculating risk but in your case NT is normal therefore CRL was not used to make the calculation.
5. In your case, the value of PAPP-A and free beta HCG blood test is on normal side, therefore there is below average risk. Please remember that these tests are providing risks only. Higher invasive tests are done only if the basic tests show high risk and this is done in genetic clinics from 16 to 19 weeks of gestation in most cases. Therefore any basic test is not 100 percent accurate but most likely acceptable.
Hope your query is answered.
Please do write back if you have any doubts.
Regards,
Note: For detailed guidance on genetic screening consult a genetics specialist
Above answer was peer-reviewed by :
Dr. Chakravarthy Mazumdar
Answered by
Get personalised answers from verified doctor in minutes across 80+ specialties
