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What Causes Hematuria While Suffering From Leukocytoclastic Vasculitis?

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Posted on Mon, 14 Dec 2015
Question: Hello Doc, I am suffering of Luckoclastic Vasculaties from last 2 month. one month back my RBC count in urine was 15-20, after 10 days it become 5-7. Today i have done again & it shows 40-60 RBC/HPF. I am taking steroid drug( Omnacortil-30MG). My age-49, Blood pressure Normal, No Sugar problem.
Pls suggest.
doctor
Answered by Dr. Indranil Ghosh (1 hour later)
Brief Answer:
may need higher doses of steroids

Detailed Answer:
Hi
Thanks for your query.

It seems like an autoimmune disease. Have we done Ana and XXXXXXX antibodies?

In any case, as the RBC in urine has increased recently, I think you need higher doses of steroids. From 10 you have come to 30, was it hiked only recently?

If required, we can add other immunosuppressive drugs like cyclophosphamide, azathioprine or rituximab.

Hope this helps. I will be available for follow up.
Regards
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Indranil Ghosh (17 hours later)
Hi Dr,
Last month i had taken 30MG streroid for 15days, then 10day-20MG & then 15days-10MG.
This month after relapse the red spot i started taking 30MG in last 7days.

I have attached the ANA & XXXXXXX report. C3 &C4 report also attached

I also done the blood report of CYROGLOBULINS PANEL, Report not received.

Pls suggest the medicine & dose.
doctor
Answered by Dr. Indranil Ghosh (7 hours later)
Brief Answer:
ok then stroids should be good

Detailed Answer:
this appears to be ANA and XXXXXXX negative vasculitis. Cryoglobulins to be checked definitely. Also serum protein electrophoresis, hep B and C tests and echo may be required to look for potential causes. Also exclude any recent drugs taken which might cause hypersensitivity vasculitis.

Now steroids can be increased further if required then slowly reduce if symptoms controlled.

If required still, antihistaminics and/or colchicine can help. For exact meds and doses, you can discuss with your rheumatologist.
Above answer was peer-reviewed by : Dr. Vinay Bhardwaj
doctor
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Follow up: Dr. Indranil Ghosh (42 minutes later)
Thank you Dr.
Can you help me about the reason & origin of this disease?
What is the source of this infection?
Last few days i have done lots of test, even i have done Biopsy of that RED patch & tissue. Awaiting for report which is expected on 26th Nov'15.

I am very worried, I am doing service & i am in leave for last 45 days.

Please suggest what to do?
doctor
Answered by Dr. Indranil Ghosh (12 hours later)
Brief Answer:
need a good rheumatologist opinion

Detailed Answer:
This is a chronic problem. The source and origin of this condition is usually not known. However you need thorough evaluation under care of a rheumatologist. Moreover this illness will take long time of treatment. Overall you are on the right track.

Have patience, get good rheumatologist opinion and I am sure it can be controlled with modern day medicines.

You can join your duties if generally you feel well.
Above answer was peer-reviewed by : Dr. Prasad
doctor
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Follow up: Dr. Indranil Ghosh (12 hours later)
Sir, Today i have received the PROTEIN, TOTAL, 24-HOUR URINE report. I am attaching that report for you.
doctor
Answered by Dr. Indranil Ghosh (7 hours later)
Brief Answer:
marginally high

Detailed Answer:
Protein in urine over 24 hrs is 400 mg per day which is only marginally high. This much is expected considering the RBC s. Red cells carry lot of protein in them, so this is expected. Will not change any treatment but will help in monitoring response.
Note: Do you have more questions on diagnosis or treatment of blood disorders? Ask An Expert/ Specialist Now

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
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Dr. Indranil Ghosh

Oncologist

Practicing since :2004

Answered : 1712 Questions

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What Causes Hematuria While Suffering From Leukocytoclastic Vasculitis?

Brief Answer: may need higher doses of steroids Detailed Answer: Hi Thanks for your query. It seems like an autoimmune disease. Have we done Ana and XXXXXXX antibodies? In any case, as the RBC in urine has increased recently, I think you need higher doses of steroids. From 10 you have come to 30, was it hiked only recently? If required, we can add other immunosuppressive drugs like cyclophosphamide, azathioprine or rituximab. Hope this helps. I will be available for follow up. Regards