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What Are The Side Effects When Cymbalta And Celexa Are Taken Together?

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Posted on Mon, 17 Nov 2014
Question: I accidently took Cymbalta 60 as well as Celexa 50 i did not know both were antidepressants. I also took my usual 100 mg Tramodol
what will happen to me? I just took them about 10 minutes ago.
doctor
Answered by Dr. Michelle Gibson James (20 minutes later)
Brief Answer:
most serious potential effect-serotonin syndrome

Detailed Answer:
HI, thanks for using healthcare magic

Celexa and cymbalta both act by increasing the levels of serotonin.

High levels of serotonin can potentially result in a condition called the serotonin syndrome. This is the most serious potential complication but because you only took one set of a double dose, it is unlikely to occur.
It would be more likely if the serotonin levels persistently high.
Tramadol can , unfortunately also cause increased level of serotonin.

To note signs and symptoms of the serotonin syndrome are confusion, sweating, change in blood pressure and heart rate,fever, shivering, hallucinations, tremor, muscle spasm, incoordination.
As mentioned , because you only took this double dose once, it is unlikely to occur.

Other potential but less harmful complications would be nausea, indigestion, sleep disturbance.

If any effects are going to occur, they will likely occur within the first 12 to 24 hours.

You may not have any effects at all.

You may want to speak to any other persons living with you , friends or family to let them know of this accidental dosing so that they may be aware of potential complications and look out for you.
You may also want to contact your doctor, he or she may suggest withholding a dose tomorrow.

In addition, after this acute problem, you may want to speak to your doctor regarding the use of tramadol with an SSRI (this type of antidepressant).
In general, because of the risk, the combination should only be used if the benefits outweigh the potential risks.

I hope this helps, feel free to ask any other questions
Note: For further guidance on mental health, Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Michelle Gibson James

General & Family Physician

Practicing since :2001

Answered : 16808 Questions

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What Are The Side Effects When Cymbalta And Celexa Are Taken Together?

Brief Answer: most serious potential effect-serotonin syndrome Detailed Answer: HI, thanks for using healthcare magic Celexa and cymbalta both act by increasing the levels of serotonin. High levels of serotonin can potentially result in a condition called the serotonin syndrome. This is the most serious potential complication but because you only took one set of a double dose, it is unlikely to occur. It would be more likely if the serotonin levels persistently high. Tramadol can , unfortunately also cause increased level of serotonin. To note signs and symptoms of the serotonin syndrome are confusion, sweating, change in blood pressure and heart rate,fever, shivering, hallucinations, tremor, muscle spasm, incoordination. As mentioned , because you only took this double dose once, it is unlikely to occur. Other potential but less harmful complications would be nausea, indigestion, sleep disturbance. If any effects are going to occur, they will likely occur within the first 12 to 24 hours. You may not have any effects at all. You may want to speak to any other persons living with you , friends or family to let them know of this accidental dosing so that they may be aware of potential complications and look out for you. You may also want to contact your doctor, he or she may suggest withholding a dose tomorrow. In addition, after this acute problem, you may want to speak to your doctor regarding the use of tramadol with an SSRI (this type of antidepressant). In general, because of the risk, the combination should only be used if the benefits outweigh the potential risks. I hope this helps, feel free to ask any other questions