Brief Answer:
It's either due to Warfarin or due to Neuropathic issues -Both will resolve

Detailed Answer:
Hi!

I understand that you have had fractures of the legs and are scheduled for a knee replacement. The sort of tingling and numbness that you experience, in the toes is a neurological issue, and I suspect that there is compression of the peroneal nerve in the course of your injury which is not uncommon. Therefore I feel that the doctors are not discussing this in detail because this issue will vanish after the surgery. However, since you are taking medications for depression, it is well known that Desvenlafaxine, an anti depressant, helps in these neuropathic pains.

The other palliative drug is Carbamazepine. I mentioned Desvenlafaxine as you would get both the benefit of the antidepressant and the tingling and numbness would come down significantly.

There is another very real possibility. We both know that Warfarin is notorious for interacting badly with broad range of other drugs given for other purposes.
This could be a drug interaction, particularly the way you describe the swelling and purple discoloration of the toe.

However, we know that once Warfarin, now necessary, is stopped, this will go away.

Tell me what you think.

Thanks,
Dr. Neel Kudchadkar

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