Brief Answer: Need to use augmentation strategies Detailed Answer: Hello, Thanks for choosing health care magic for posting your query. I have gone through your question in detail and I can understand what you are going through. Its unfortunate that your depression has lasted for this long. Over years many new treatment options for depression have cropped up and they are all very effective. Its very natural to switch an antidepressant to a new one if there are no improvement. Further if antidepressants are not effective then they need to be augmented with an antipsychotic or lithium or thyrod supplimentation. These augmentation process helps improve the efficacy of antidepressants and especially helps in resistant depression. Also there is a new therapy with injectable kitamine which helps in improving the mood. They need to be done every week for 3-4 weeks and will show gradual improvement. Hope I am able to answer your concerns. If you have any further query, I would be glad to help you. If not, you may close the discussion and if possible you may rate the answer for me, so that I get a good feedback. In future if you wish to contact me directly, you can use the below mentioned link: bit.ly/dr-srikanth-reddy Wish you good health, Kind regards Dr. Srikanth Reddy M.D.

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