Brief Answer:
There is not much evidence available about thiamine deficiency in pregnancy

Detailed Answer:
Hello, and I hope I can help you today.

Thiamine deficiency is not commonly seen in Western countries except in the cases of severe alcoholism. In certain developing countries, it can be the result of inadequate dietary consumption.

Thiamine deficiency can be treated with IV thiamine, which is regarded as safe during pregnancy when medically necessary, or oral supplements, depending on the severity.

I was only able to find animal studies of the effects of thiamine in pregnancy during a medical literature review. One study in rats concluded that the fetuses of thiamine deficient rats exhibited nerve degeneration in their brains similar to human Alzheimer's disease.

Because this patient's thiamine deficiency was diagnosed at five months of pregnancy is not possible to know what effect this may have had on the development of the fetus.

So in summary, thiamine deficiency during pregnancy is treatable, and eventually reversible, however the potential effects on the fetus are unknown.

I suggest that you consult with a maternal fetal medicine specialist who may survey the baby by ultrasound and recommend most effective dosing schedule and treatment for the thiamine deficiency.

I hope that I was able to adequately answer your question, and that my advice was helpful. If you need anything further, please do not hesitate to contact me.

Best wishes for the pregnancy,

Dr. Brown

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