Brief Answer:
Right combination of factors is needed for testosterone to bring the changes

Detailed Answer:
Thanks for asking on HealthcareMagic.

Biochemically testosterone will always bind to androgen receptors in any condition when either of them are present. But the binding is just the first step of a cascade of reactions that ultimately leads to the pubertal changes. Before puberty this cascade is not ready and hence the effects like voice changes do not occur. It is like the fact that irrespective of how many times you open the conference gates, until the time of the conference actually arrives, people will not arrive or accumulate and the conference will not start. It is true that the amount of testosterone is insufficient but giving a large dose of testosterone will not make puberty start when it is not due.

Hope that answers your questions.

If you found my answer helpful, please close the thread with a positive review and a 5 star rating.

Regards
Dr. Diptanshu Das

---

Brief Answer:
CAH is characterised by excess androgens and true early puberty

Detailed Answer:
Thanks for writing back.

CAH or congenital adrenal hyperplasia is a condition caused dut to high concentrations of androgens in utero. It may be associated with androgen insensitivity. Some children with CAH develop true precocious puberty with early maturation of the hypothalamic-pituitary-gonadal axis (central puberty). That is because the entire system gets fast forwarded due to the excess of androgens.

Hope that explains your queries.

Regards
Dr. Diptanshu Das

---

Brief Answer:
During'mini puberty' androgens would be binding to their receptors

Detailed Answer:
Thanks for writing back.

During the male baby 'mini puberty' (which is actually true puberty, just a little early), androgens would definitely binding to the androgen receptors wherever they are, including those concerned with voice/bone/hair follicle tissues.

Hope that answers your queries.

Regards
Dr. Diptanshu Das

---

Brief Answer:
The endogenous androgens were doing their work much before treatment

Detailed Answer:
Thanks for writing back.

Let me confirm that the first effect of the endogenous androgens was much earlier than any treatment possible. In fact, the excess of androgens was what triggered the early onset of puberty and pubertal changes including increased hair growth and voice changes. Let me mention that hormones acts by triggering or facilitating certain chemical reactions which need not be at the site of action. So, it does not really matter where the androgen receptors are located, they are programmed to perform certain actions when the hormone is available to trigger them. Thus the availability of androgens makes them bind to the androgen receptors and the effect is increased hair growth or deepening of voice.

Hope that helps.

If you found my answer to be helpful, please close the thread with a positive review and a 5 star rating.

Regards
Dr. Diptanshu Das

---

Brief Answer:
There is physiological basis for the HPG axis not to regress completely

Detailed Answer:
Thanks for asking again. Wish you a Happy New Year.

The hypothalamic–pituitary–gonadal axis (HPG axis) refers to the effects of the hypothalamus, pituitary gland, and gonads as if these individual endocrine glands were a single entity as a whole. This axis controls development, reproduction, and aging in animals. All of them remain functional much later in our life. The coordination remains persistent in the form of a feedback mechanism. So there is no reason for complete physiological dissociation of the components of this axis although the coordination may eventually come down. Hence that is the scientific and physiological explanation behind the existent activity.

Hope that helps.

Regards
Dr. Diptanshu Das

---

Brief Answer:
It is just a preparatory phase for a more intense phase called puberty

Detailed Answer:
Thanks for asking back again.

I have already explained in my last answer that there is no reason for complete dissociation in the function of the hypothalamus, pituitary and the gonads even during the juvenile pause. I think that you got the concept slightly wrong. I can give you an analogy which can make you understand. It is like a car backing up (no forward movement) from the starting like before picking up the gear to accumulate speed before the final take off on a long trajectory. The juvenile pause is just a pause (characterised by active preparation) to gear up for the rapid changes that bring the puberty. This is a transient dip and not a permanent one. In fact, it gives way to a more active HPG axis.

Going through the following scientific writings may be of help:
http://www.macpeds.com/documents/RegulationandDisordersofPubertalTiming.pdf
http://www.ncbi.nlm.nih.gov/pubmed/0000

In case you are satisfied with the answer, please care to leave a positive review and a 5 star rating.

Regards
Dr. Diptanshu Das

---

Brief Answer:
Treatment stimulated testosterone could not have been the first

Detailed Answer:
Thanks again.

The testosterone given as the treatment could not be the initial testosterone to bind to its receptors. You have already alive for n number of years prior to that when the endogenous testosterone of your body was doing the same. Irrespective of the amount, testosterone would definitely have been there right from your birth and even before that. So, the testosterone given for treatment or stimulated by the treatment could not have been the first testosterone to act.

Hope that helps.

---

Brief Answer:
Irrespective of age and sex the receptors are present

Detailed Answer:
Thanks again.

In the early period even before you were born, you have been exposed to high testosterone and the receptors were still present at that time, it is only that the system was not yet mature to bring about all the changes immediately, but it was definitely in process. Irrespective of whether in a baby or in teen or adult, and irrespective of the gender, the receptors are present where they are supposed to be.

I understand your inquisitiveness, but you must also understand that scientific literature is very technical in nature and unless you already have the capacity to read them (which many doctors even lack), you might misinterpret what they really mean.

Hope to have been of help.

Regards
Dr. Diptanshu Das

---