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How Long Does Anaplastic Thyroid Carcinoma Take To Respond To Chemotherapy?

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Posted on Mon, 12 Oct 2015
Question: My father is having cancer of type Anaplastic Thyroid carcinoma.. He was given 3 cycles of Chemotherapy... medicine given was Paclitaxel 260 mg, Carboplatin 450 mg ...After two months of treatment, we are not seeing any significant change in the reports... Could you please help..
doctor
Answered by Dr. Indranil Ghosh (23 minutes later)
Brief Answer:
It responds poorly to chemo

Detailed Answer:
Hi
I understand your concerns.

Anaplastic thyroid carcinoma is difficult to treat. It usually does not respond well to chemo or radiotherapy. You have not mentioned that there is no change, does that mean stable disease? If it is even stable, then we can take it as response and continue the chemo.

If disease is increasing, then we can try doxorubicin chemo. There some case reports of sorafenib or everolimus producing some responses and can be tried as well.

But overall result is not good.

I am really sorry I could not suggest much but that is the reality in this disease.

Regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Indranil Ghosh (27 minutes later)
yes.. the size of the different modules is increasing slowly... I understand that treatment for this is quite difficult...
Thanks for your response.
doctor
Answered by Dr. Indranil Ghosh (34 minutes later)
Brief Answer:
Then we should change the treatment

Detailed Answer:
We have to change the treatment and see the response again.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Indranil Ghosh (18 minutes later)
Could you please suggest any specific treatment which would be the best for this case ?
Thanks
doctor
Answered by Dr. Indranil Ghosh (10 hours later)
Brief Answer:
can try doxorubicin chemo

Detailed Answer:
You can send me the latest scan reports which may be useful.
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Indranil Ghosh (6 minutes later)
Attached is the PET scan report
doctor
Answered by Dr. Indranil Ghosh (4 hours later)
Brief Answer:
see below

Detailed Answer:
doxorubicin chemo is a valid option. Can also try sorafenib tablet. if no response then everolimus
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Indranil Ghosh (13 minutes later)
Thank you
doctor
Answered by Dr. Indranil Ghosh (5 hours later)
Brief Answer:
you are welcome

Detailed Answer:
Regards
Note: For further queries related to kidney problems Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
Answered by
Dr.
Dr. Indranil Ghosh

Oncologist

Practicing since :2004

Answered : 1712 Questions

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How Long Does Anaplastic Thyroid Carcinoma Take To Respond To Chemotherapy?

Brief Answer: It responds poorly to chemo Detailed Answer: Hi I understand your concerns. Anaplastic thyroid carcinoma is difficult to treat. It usually does not respond well to chemo or radiotherapy. You have not mentioned that there is no change, does that mean stable disease? If it is even stable, then we can take it as response and continue the chemo. If disease is increasing, then we can try doxorubicin chemo. There some case reports of sorafenib or everolimus producing some responses and can be tried as well. But overall result is not good. I am really sorry I could not suggest much but that is the reality in this disease. Regards