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Does D-limonene Extracted By Cold Pressing Grapefruit Peels Cause Allergy?

Posted on Wed, 18 Mar 2015

Question: yes, i want to know if the d-limonene extracted by cold pressing grapefruit peels will have an adverse effect on the sirolimus i take for my kidney transplant? I am aware of the contraindication for grapefruit juice but i wonder if the same holds true for the chemical d-limonene extracted from the peels. please reply.
thank you

Answered by Dr. Rakesh Madhyastha (1 hour later)

Brief Answer:
No documented interaction known

Detailed Answer:
Hello

Thanks for the query

I have gone through the interaction check and there is no documented interaction profile between them.
Here is what I suggest

1. Speak to your doctor about starting limonene
2. Check your sirolimus level on day 2 and one week after starting limonene.

Monitoring of the sirolimus is the only way to find out the interaction

I hope I was of help, if you have any further queries please get back to me

Regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Rakesh Madhyastha (26 minutes later)

i don't think i am willing to take the chance there might be a negative interaction. can you suggest a safer better way to curb my appetite to lose weight?

Answered by Dr. Rakesh Madhyastha (2 hours later)

Brief Answer:
Wise decision

Detailed Answer:
Hello

Thanks for getting back

I think you have taken a wise decision by going against taking this drug.
Your weight issues could be secondary to some of the drugs you are taking.
Please get back to me with the drugs you are on currently

Regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Rakesh Madhyastha (9 hours later)

i take prednisone and sirolimus for my kidney transplant. i take citalopram, divalproex, and risperidone for mental illness symptoms. i take multivitamins and ceterizine for general health.

Answered by Dr. Rakesh Madhyastha (5 hours later)

Brief Answer:
prednisone can cause weight gain

Detailed Answer:
Hello

Thanks for the query

Prednisone can cause some amount of weight gain however this is an important drug for preventing rejection of the renal graft.
Here is what I suggest

1. Exercise daily for atleast 30 min a day, if you have a smartphone make sure you click 10,000 steps on the pedometer a day
2. Make sure your meals are not rich in carbs, the best way to reduce carbs is by adding more fiber. For example more vegetables in your pasta
3. consciously make an effort to avoid sugar
4, avoid dessert
5. Track your weight on a weekly basis and keep monthly targets

I hope I was of help, if you have any queries get back to me.
Just as a curiosity being a nephrologist could you let me know your current serum creatinine ,date of transplant and donor details

thanks
regards

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar

Follow up: Dr. Rakesh Madhyastha (24 hours later)

yes, i received my transplant august 7, 2011. My creatinine is 0.9 and my donor was a man who lost his life in an automobile accident 3000 miles away. I have had no problems with the kidney since transplant. I had the surgery done at the veterans hospital in XXXXXXX Oregon, USA. They have a very good program and the surgery went very well. thank you for your advice.

Answered by Dr. Rakesh Madhyastha (3 hours later)

Brief Answer:
Thank you

Detailed Answer:
Hello

Thank you for getting back to me. I am happy that you are doing well. In our center we give triple immunosupression, mostly tacrolimus with mycophenolate mofetil and steroids. Success rate is about 93% last year with 5 year graft survival about 86%.

Let me know if you need help with anything else

Regards

Note: For further queries related to kidney problems and comprehensive renal care, talk to a Nephrologist. Click here to Book a Consultation.

Above answer was peer-reviewed by : Dr. Yogesh D