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Does Wellbutrin And Lexapro Help Cure Depression?

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Posted on Sat, 9 Jan 2016
Question: Dear doctor, I have been taking Wellbutrin and Lexapro for a couple of months. We cut the Wellbutrin back when I started to have prickly skin and aching stomach. Then later I was given Hydroxyzine Pamoate for the prickly skin, etc. The pricklies went away but my stomach got worse, with acid from anxiety; I used the H-P and the pricklies never came back much so I stopped it quickly. I was advised by an emergency room doctor to go back and take the H-Pamoate, but since then it seems I have been getting more and more depressed for no reason. Last night for the first time I took an H-P to assure my sleeping well, which it did, but I was depressed right away in the morning which has not happened to me before. The depression got worse when I started taking H-P again, I think, but only recently later in the day after I have taken H-P in the morning and in the afternoon. Today I started feeling very depressed right away in the morning. Could the H-P be making more depressed?
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Answered by Dr. Anshul Varshney (7 hours later)
Brief Answer:
Wellbutrin related.

Detailed Answer:
Welcome To HCM. I am Dr Anshul Varshney. I understand your concern.
It's very unlikely that H-P is aggravating your depression issues.
Most probably your depression is being aggravated as you have been cutting off Wellbutrin.
Aggravation of depression is a prominent side effect while cutting down or stopping Wellbutrin.
I suppose you should be adding up either another anti depressant with Lexapro or increase the dose of Lexapro.
My recommendations would be to add up Paroxetine (SSRI) for the purpose.
Once you start improving , gradually taper the dose and stop it.
Also start with meditation and exercises.
I hope it helps you.
If you have any further query, please ask me.
Note: For further guidance on mental health, Click here.

Above answer was peer-reviewed by : Dr. Prasad
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Answered by
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Dr. Anshul Varshney

Internal Medicine Specialist

Practicing since :2009

Answered : 3071 Questions

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Does Wellbutrin And Lexapro Help Cure Depression?

Brief Answer: Wellbutrin related. Detailed Answer: Welcome To HCM. I am Dr Anshul Varshney. I understand your concern. It's very unlikely that H-P is aggravating your depression issues. Most probably your depression is being aggravated as you have been cutting off Wellbutrin. Aggravation of depression is a prominent side effect while cutting down or stopping Wellbutrin. I suppose you should be adding up either another anti depressant with Lexapro or increase the dose of Lexapro. My recommendations would be to add up Paroxetine (SSRI) for the purpose. Once you start improving , gradually taper the dose and stop it. Also start with meditation and exercises. I hope it helps you. If you have any further query, please ask me.