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Does Tramadol Interact With Paroxetine?

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Posted on Mon, 22 Aug 2016
Question: Can tramadol 37.5 5/325 bee taken w/paroxetine,
doctor
Answered by Dr. Michelle Gibson James (28 minutes later)
Brief Answer:
there is a potential interaction

Detailed Answer:
HI, thanks for using healthcare magic

Tramadol is opiate though it is a weak opiate.

There are two possible interactions between tramadol and paroxetine.

Paroxetine can affect the levels/effectiveness of tramadol. It decreases the conversion/change of tramadol from the original form to the active form in the body.
This means that it can cause decreased activity of the tramadol.

Both of these drugs also increase serotonin levels. Serotonin can cause serious problems if its levels become too high so the combination would need to be monitored.

Hydrocodone/paroxetine combination does not cause increased serotonin but the paroxetine can increase the levels of the hydrocodone

I hope this helps, feel free to ask any other questions

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
doctor
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Follow up: Dr. Michelle Gibson James (7 days later)
I had an ESI, L4S1 interlaminal(sp) today . As advised, I stopped taking plavix 5 days prior. Why was this? I don't like to stop plavix for fear of cva Have not had cva z but have had tias,
doctor
Answered by Dr. Michelle Gibson James (11 hours later)
Brief Answer:
to reduce risk of bleeding

Detailed Answer:
HI

Sorry about the delayed reply

It is understandable, with a history of previous TIAs to be concerned about stopping plavx.

With any injection there is a potential risk of bleeding. With the use of an anticoagulant such as plavix, the risk of bleeding increases even more

To make sure that there is no excess bleeding, they would have suggesting the plavix is discontinued for a bit

Please feel free to ask anything else
Note: For further guidance on mental health, Click here.

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Michelle Gibson James

General & Family Physician

Practicing since :2001

Answered : 16808 Questions

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Does Tramadol Interact With Paroxetine?

Brief Answer: there is a potential interaction Detailed Answer: HI, thanks for using healthcare magic Tramadol is opiate though it is a weak opiate. There are two possible interactions between tramadol and paroxetine. Paroxetine can affect the levels/effectiveness of tramadol. It decreases the conversion/change of tramadol from the original form to the active form in the body. This means that it can cause decreased activity of the tramadol. Both of these drugs also increase serotonin levels. Serotonin can cause serious problems if its levels become too high so the combination would need to be monitored. Hydrocodone/paroxetine combination does not cause increased serotonin but the paroxetine can increase the levels of the hydrocodone I hope this helps, feel free to ask any other questions