Brief Answer: Sivastatin and Amlodipine may be contributing Detailed Answer: Hi and thank you so much for this query. I am so sorry to hear about this sexual difficulties. This is always a source of worries to most persons and it is totally understandable. I hope we get to find solutions that would be able to get you performing at your best again. From the list of medications you have provided, amlodipine and simvastatin can contribute towards sexual weakness. However, these are not the most common side effects of these medications but does not exclude the fact that they may be the source of the problem. For the meantime, I will suggest that you get a sincere and honest talk with your partner. Let her understand it is as much a problem to you and how exactly you feel about it. Plead with her to be supportive and bear with you while you try to get the problem figured out and corrected. The unfortunate thing with sexual impotence is that each failed experience prepares you for the next failure. This is because you become too concerned about your failures and fail to even get focused on the main task of getting erections and performing. It takes real motivation to dig your way out of this. At times working with sex experts really helps. For now, I will like that you contact the doctor who prescribed the above medications to you and let him understand that you have serious sexual difficulties. He may want to change them to others that have no known effects on sex so that we can step away from accusing the drugs as the possible cause. Also, he will have the chance to examine you and figure out if there is any other identifiable cause that we ay be missing at this time. One major way to tell whether you have a psychological cause of impotence from that caused by a disease is that you should monitor and see whether you have early morning erections as you wake up from sleep. If you do, then this problem would most likely be psychological and rebuilding your confidence would be of great help, too. I hope you find this helpful. Thank you so much for using our services and please do feel free to ask for clarifications if need be. I wish you the best of health. Dr. Ditah, MD.