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DOES CHLAMYDIA TRACHOMATIS INFECTION A TRIGGER FOR LUPUS ERYTHEMATOSUS ?
Question:
hello !
I remember you as a great expert !
I have question does CHLAMYDIA TRACHOMATIS INFECTION A TRIGGER FOR LUPUS ERYTHEMATOSUS ?
Or risk is very small for CHLAMYDIA TRACHOMATIS develop - Systemic Lupus Erythematosus
There is only one study - and it is no serious - if there would be such association there should be lot of such publications !
The question does CHLAMYDIA TRACHOMATIS lead to CHLAMYDIA TRACHOMATIS ? ( or risk is very small - and low association - as there is only one study what i found !
https://www.researchgate.net/publication/0000_IS_CHLAMYDIA_TRACHOMATIS_INFECTION_A_TRIGGER_FOR_LUPUS_ERYTHEMATOSUS_MPS_Sawhney_VP_Chaturvedi_S_Arora
Twenty three (88.46%) of the cases were females and three (11.54%) were males with an average age of 31.23 years (SD 4.33 years). Forty one (87.23%) and 6 (12.77%) of controls were females and males respectively with an average age of 30.14 years (SD 3.35 years). The difference in mean ages between cases and controls was not found significant (P> 0.05). Eight (30.77%) cases and 3 (6.38%) controls tested positive for C. trachomatis antibodies. This difference was found statistically significant (2 df = 1 P < 0.01 with Odds ratio of 6.62, there is 5.0 to 43.2% higher chance of developing SLE in patients with seropositivity for C. trachomatis
2. Questing - in this study it is said that
While seeing cases of SLE, we noticed that many of them had associated pelvic inflammatory disease (PID). Since Chlamydia trachomatis is one of the most common causes of PID and it is known to initiate HSP-60 induced CD8+ T-cell mediated cytotoxicity by molecular mimicry in Reiter’s disease, we decided to look for evidence of C. trachomatis infection in patients of SLE.
And again - does SLE is causes by pelvic inflammatory disease or its is associated with that SLE patients have lower immunity and they are more likely to get pelvic inflammatory disease from some pathogens like Gardnerella vaginalis not C. trachomatis
Thank you very much !
hello !
I remember you as a great expert !
I have question does CHLAMYDIA TRACHOMATIS INFECTION A TRIGGER FOR LUPUS ERYTHEMATOSUS ?
Or risk is very small for CHLAMYDIA TRACHOMATIS develop - Systemic Lupus Erythematosus
There is only one study - and it is no serious - if there would be such association there should be lot of such publications !
The question does CHLAMYDIA TRACHOMATIS lead to CHLAMYDIA TRACHOMATIS ? ( or risk is very small - and low association - as there is only one study what i found !
https://www.researchgate.net/publication/0000_IS_CHLAMYDIA_TRACHOMATIS_INFECTION_A_TRIGGER_FOR_LUPUS_ERYTHEMATOSUS_MPS_Sawhney_VP_Chaturvedi_S_Arora
Twenty three (88.46%) of the cases were females and three (11.54%) were males with an average age of 31.23 years (SD 4.33 years). Forty one (87.23%) and 6 (12.77%) of controls were females and males respectively with an average age of 30.14 years (SD 3.35 years). The difference in mean ages between cases and controls was not found significant (P> 0.05). Eight (30.77%) cases and 3 (6.38%) controls tested positive for C. trachomatis antibodies. This difference was found statistically significant (2 df = 1 P < 0.01 with Odds ratio of 6.62, there is 5.0 to 43.2% higher chance of developing SLE in patients with seropositivity for C. trachomatis
2. Questing - in this study it is said that
While seeing cases of SLE, we noticed that many of them had associated pelvic inflammatory disease (PID). Since Chlamydia trachomatis is one of the most common causes of PID and it is known to initiate HSP-60 induced CD8+ T-cell mediated cytotoxicity by molecular mimicry in Reiter’s disease, we decided to look for evidence of C. trachomatis infection in patients of SLE.
And again - does SLE is causes by pelvic inflammatory disease or its is associated with that SLE patients have lower immunity and they are more likely to get pelvic inflammatory disease from some pathogens like Gardnerella vaginalis not C. trachomatis
Thank you very much !
Brief Answer:
Not likely to have a direct association
Detailed Answer:
Hello,
I would say that any infection or some stressful condition can always precipitate SLE, so I wouldn't say that there is any one particular infection that has been known to trigger SLE like in reiters disease. There are specific infections which cause gastrointestinal and genitourina ryinfections like chlymydiae or shigella or salmonella, which can trigger reiters. But the same has not really been found with sle. The other thing about pelvic inflammatory diseases, also, there is no direct correlation. It's just that probably people with like you said, people with sle have lower immunity and they may be on drugs, which can lower immunity and therefore they may have a higher tendency to develop infections .
regards.
Not likely to have a direct association
Detailed Answer:
Hello,
I would say that any infection or some stressful condition can always precipitate SLE, so I wouldn't say that there is any one particular infection that has been known to trigger SLE like in reiters disease. There are specific infections which cause gastrointestinal and genitourina ryinfections like chlymydiae or shigella or salmonella, which can trigger reiters. But the same has not really been found with sle. The other thing about pelvic inflammatory diseases, also, there is no direct correlation. It's just that probably people with like you said, people with sle have lower immunity and they may be on drugs, which can lower immunity and therefore they may have a higher tendency to develop infections .
regards.
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Above answer was peer-reviewed by :
Dr. Kampana
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