hello doctor (30 years, male), i am suffering from medicinal lymphadenopathy of right paracial lymph node ,biopsy confirm tb , sensitivity report resistant to ofloxacin and moxifloxacin since last month.doctor advised me to take Isoniazide (H), Rifampicin (R), ethambutol (E) and Pyrazinamide (Z) separately for 8 days and then akurit-4, thereafter but after using it for 16 days i was effected with drug induced hepatitis (vomiting etc., sgpt 166, sopt 76) . Further my vitamin b12 level was 194 and vitamin D3 level was 8 only. doctor has said me to stop the medicine, so i stop it for 10 days .now they advised me to take combutol-1000 along with streptomycin injections(750ml) per day. my sgpt level reduced to 66 and sopt 43).

my questions are

1. does the hepatitis it due to vitamins (b12 or d3) deficiency. i have all other liver test, all negative.

2. only two medicine (combutol-1000 along with streptomycin injections(750ml) per day) is enough, doctors have said me to reintroduce the other drugs after some time.

3. what are the chance does i have already got any drug resistance. (had stopped ATT for 10 days in between with doctors advice)

4. does introduction of same drug again leads to same problem of hepatitis.