I have been using the Combi Patch 50/25 weekly for about 8 years. For the last year (I am 59) I have been slowly extending the time between new patches, up to about 18 days. I feel like I see the aging process accelerated in my face, especially the neck area. Can this have anything to do with having less hormones, due to my extended time between patches? I know this comes with aging, but it seems like it came on pretty fast. Overall I am in good physical condition, and take good care of myself. Thank you, XXXX