My wife is 67 years old,91 kg by weight and 162 cm in height.She had total removal of thyroids in 2006.Since then she is on Thyroxine Sodium tablets 100 & 25 mcg.Her BP is around 160/100.Pulse 90 or so.She takes now,Telma 80H (Telmisartan and Hydrochlorothiazide), Asomex 2.5. Earlier she was taking Envas 5mg and Asomex D since 2006,without much effect on BP. She also takes Glucosamine 1500 mg tablets daily for knee joint pain. Her continued discomforts are (i) Continuous daylong feeling of fatigue, (ii) no respite from arthritic pain without Etoshine pain killer. X-ray of knee shows gross O.A. change in both knee joints .Blood sugar is O.K.Lipid profile is O.K. What is your advice?